{"id":1851,"date":"2021-04-16T11:12:00","date_gmt":"2021-04-16T03:12:00","guid":{"rendered":"https:\/\/wingor.abvnet.com\/%e5%96%9c%e8%ae%af%ef%bc%81%e8%8c%b5%e5%86%a0%e6%88%98%e7%95%a5%e5%90%88%e4%bd%9c%e5%8c%bb%e9%99%a2%e4%b8%9c%e5%a4%a7%e9%99%84%e5%b1%9e%e4%b8%ad%e5%a4%a7%e5%8c%bb%e9%99%a2%e5%8f%96%e5%be%97%e9%87%8d\/"},"modified":"2026-05-30T18:22:24","modified_gmt":"2026-05-30T10:22:24","slug":"%e5%96%9c%e8%ae%af%ef%bc%81%e8%8c%b5%e5%86%a0%e6%88%98%e7%95%a5%e5%90%88%e4%bd%9c%e5%8c%bb%e9%99%a2%e4%b8%9c%e5%a4%a7%e9%99%84%e5%b1%9e%e4%b8%ad%e5%a4%a7%e5%8c%bb%e9%99%a2%e5%8f%96%e5%be%97%e9%87%8d","status":"publish","type":"post","link":"https:\/\/wingor.abvnet.com\/en\/news\/%e5%96%9c%e8%ae%af%ef%bc%81%e8%8c%b5%e5%86%a0%e6%88%98%e7%95%a5%e5%90%88%e4%bd%9c%e5%8c%bb%e9%99%a2%e4%b8%9c%e5%a4%a7%e9%99%84%e5%b1%9e%e4%b8%ad%e5%a4%a7%e5%8c%bb%e9%99%a2%e5%8f%96%e5%be%97%e9%87%8d\/","title":{"rendered":"\u559c\u8baf\uff01\u8335\u51a0\u6218\u7565\u5408\u4f5c\u533b\u9662\u4e1c\u5927\u9644\u5c5e\u4e2d\u5927\u533b\u9662\u53d6\u5f97\u91cd\u5927\u8fdb\u5c55"},"content":{"rendered":"<div>\n<div>\n<!--article detail--><\/p>\n<div>\n<div>\n<div>\n<div>\n<div>\n<p><span><span>\u81ea2019\u5e744\u670826\u65e5\uff0c\u8335\u51a0\u751f\u7269\u4e0e\u4e1c\u5357\u5927\u5b66\u9644\u5c5e\u4e2d\u5927\u533b\u9662\u6b63\u5f0f\u7b7e\u7f72\u300a\u751f\u7269\u533b\u5b66\u65b0\u6280\u672f\u7814\u7a76\u4e0e\u8f6c\u5316\u5e94\u7528\u6218\u7565\u5408\u4f5c\u534f\u8bae\u300b\u4ee5\u6765\uff0c\u53cc\u65b9\u65e8\u5728\u751f\u7269\u533b\u5b66\u65b0\u6280\u672f\u5728\u4e34\u5e8a\u4e0a\u7684\u7814\u7a76\u4e0e\u5e94\u7528\u9886\u57df\u5f00\u5c55\u6df1\u5165\u7d27\u5bc6\u5408\u4f5c\uff0c\u6253\u9020\u53ef\u6301\u7eed\u53d1\u5c55\u7684\u6218\u7565\u5408\u4f5c\u5173\u7cfb\uff0c\u5171\u540c\u63a8\u52a8\u5e76\u5f15\u9886\u518d\u751f\u533b\u5b66\u6280\u672f\u7684\u53d1\u5c55\u3002<\/span><\/span><\/p>\n<p>\u00a0<\/p>\n<p><span><span>\u7ecf\u8fc7\u8fd1\u4e24\u5e74\u7684\u79d1\u5b66\u7814\u7a76\uff0c2021\u5e744\u67089\u65e5\uff0c\u559c\u8baf\u4f20\u6765\uff1a<span>\u4e1c\u5357\u5927\u5b66\u80be\u810f\u75c5\u7814\u7a76\u6240\u5218\u5fc5\u6210\u548c\u5415\u6797\u8389\u6559\u6388\u53d1\u73b0\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5916\u6ccc\u4f53miR-125b-5p\u901a\u8fc7\u6291\u5236p53\u4fc3\u8fdb\u7f3a\u8840\u6027AKI\u7684\u80be\u5c0f\u7ba1\u4fee\u590d<\/span>\u3002<\/span><\/span><\/p>\n<p>\u00a0<\/p>\n<p><strong><span><span><span>\u00a0\u00b7 \u6025\u6027\u80be\u635f\u4f24 \u00b7<\/span><\/span><\/span><\/strong><\/p>\n<p><span><span>\u6025\u6027\u80be\u635f\u4f24\uff08AKI\uff09\u662f\u4e34\u5e8a\u5e38\u89c1\u7684\u6025\u3001\u5371\u3001\u91cd\u75c7\uff0c\u53d1\u751f\u5728\u7ea610%-15%\u7684\u4f4f\u9662\u60a3\u8005\u53ca\u8d85\u8fc750%\u7684\u91cd\u75c7\u60a3\u8005\u4e2d\u3002\u5c3d\u7ba1\u80be\u810f\u66ff\u4ee3\u6cbb\u7597\u53ef\u7528\u4e8e\u91cd\u5ea6AKI\u7684\u652f\u6301\u6cbb\u7597\uff0c\u4f46\u76ee\u524d\u4ecd\u65e0\u786e\u5207\u6709\u6548\u7684\u7597\u6cd5\u80fd\u6301\u7eed\u4fc3\u8fdb\u80be\u529f\u80fd\u6062\u590d\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6765\u6e90\u7684\u5916\u6ccc\u4f53\uff08MSC-exos\uff09\u53ef\u80fd\u6210\u4e3a\u6cbb\u7597AKI\u7684\u65b0\u7b56\u7565\u3002<\/span><\/span><\/p>\n<p>\u00a0<\/p>\n<p><strong><span><span><span>\u00b7 \u7814\u7a76\u8fdb\u5c55 \u00b7<\/span><\/span><\/span><\/strong><\/p>\n<p><span><span>\u8fd1\u65e5\uff0c\u4e1c\u5357\u5927\u5b66\u80be\u810f\u75c5\u7814\u7a76\u6240\u5218\u5fc5\u6210\u548c\u5415\u6797\u8389\u6559\u6388\u56e2\u961f\u6210\u5458\u5728\u751f\u7269\u533b\u5b661\u533a\u6742\u5fd7\u300aTheranostics\u300b\uff082019 IF: 8.579\uff09\u4e0a\u53d1\u8868\u8bba\u6587\uff0c\u62a5\u9053\u4e86MSC-exos\u901a\u8fc7miR-125b-5p\/p53\u4fc3\u8fdb\u80be\u5c0f\u7ba1\u4fee\u590d\u4ece\u800c\u6539\u5584\u7f3a\u8840\u6027AKI\u7684\u5177\u4f53\u673a\u5236\uff0c\u8be5\u7814\u7a76\u4e3aMSC-exos\u4e34\u5e8a\u5e94\u7528\u4e8e\u7f3a\u8840\u6027AKI\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u7406\u8bba\u4f9d\u636e\u3002<\/span><\/span><\/p>\n<p>\u00a0<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" alt=\"\" height=\"535\" src=\"https:\/\/wingor.abvnet.com\/wp-content\/uploads\/2026\/05\/30567284.png\" width=\"780\"><\/p>\n<p>\u00a0<\/p>\n<p><span><span>\u5728\u6b64\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u8005\u5c06\u4f4e\u514d\u75ab\u539f\u6027\u3001\u6613\u83b7\u53d6\u3001\u589e\u6b96\u53ca\u4fee\u590d\u80fd\u529b\u5f3a\u7684\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u4f5c\u4e3aMSC-exos\u7684\u4f9b\u4f53\u7ec6\u80de\uff0c\u901a\u8fc7\u5dee\u901f\u79bb\u5fc3\u3001\u8fc7\u6ee4\u3001\u8d85\u6ee4\u7b49\u76f8\u7ed3\u5408\u7684\u65b9\u6cd5\u7eaf\u5316MSC-exos\uff0c\u5e76\u5e94\u7528\u4e8e\u6cbb\u7597\u53cc\u4fa7\u7f3a\u8840\u518d\u704c\u6ce8AKI\u5c0f\u9f20\u3002\u8be5\u7814\u7a76\u63a2\u8ba8\u4e86MSC-exos\u5f52\u5de2\u81f3\u635f\u4f24\u80be\u810f\u53ca\u80be\u5c0f\u7ba1\u7684\u53ef\u80fd\u673a\u5236\uff0c\u5e76\u53d1\u73b0MSC-exos\u53ef\u5c06miR-125b-5p\u4f20\u9012\u81f3\u80be\u5c0f\u7ba1\uff0c\u4ece\u800c\u4fee\u590d\u635f\u4f24\u5c0f\u7ba1\u3002<\/span><\/span><\/p>\n<p>\u00a0<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/wingor.abvnet.com\/wp-content\/uploads\/2026\/05\/30567285.png\" width=\"780\"><\/p>\n<p>\u00a0<\/p>\n<p><span><span>\u8be5\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cMSC-exos\u4e4b\u6240\u4ee5\u80fd\u6709\u6548\u5730\u5f52\u5de2\u81f3\u635f\u4f24\u7684\u80be\u810f\uff0c\u5e76\u5b9a\u4f4d\u4e8e\u8fd1\u7aef\u5c0f\u7ba1\uff0c\u4e3b\u8981\u662f\u7531MSC-exos\u7684\u6574\u5408\u7d20VLA-4\u3001LFA-1\u4e0e\u635f\u4f24\u80be\u5c0f\u7ba1\u7684VCAM-1\u3001ICAM-1\u7ed3\u5408\u6240\u4ecb\u5bfc\u7684\u3002\u91c7\u7528\u6297\u4f53\u5c01\u95edMSC-exos\u4e0a\u7684\u6574\u5408\u7d20VLA-4\u3001LFA-1\uff0c\u5176\u5f52\u5de2\u81f3\u635f\u4f24\u80be\u810f\u7684\u80fd\u529b\u51cf\u5f31\u3002MSC-exos\u4ee5\u5242\u91cf\u4f9d\u8d56\u7684\u65b9\u5f0f\u51cf\u8f7b\u5c0f\u9f20\u7f3a\u8840\u6027AKI\u53ca\u80be\u5c0f\u7ba1\u635f\u4f24\u3002<\/span><\/span><\/p>\n<p><span><span>\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\uff0cMSC-exos\u5728\u4f53\u5185\u548c\u4f53\u5916\u5747\u80fd\u663e\u8457\u6291\u5236\u80be\u5c0f\u7ba1\u4e0a\u76ae\u7ec6\u80de\uff08TECs\uff09\u7684\u7ec6\u80de\u5468\u671f\u963b\u6ede\u548c\u51cb\u4ea1\u3002\u4ece\u673a\u5236\u4e0a\u8bb2\uff0cMSC-exos\u5bcc\u542bmiR-125b-5p\uff0c\u5e76\u53ef\u5c06miR-125b-5p\u4f20\u9012\u81f3TECs\uff0c\u901a\u8fc7\u4e0b\u8c03p53\u51cf\u8f7bTECs\u7684G2\/M\u671f\u963b\u6ede\u3001\u4fc3\u8fdb\u589e\u6b96\u3001\u51cf\u5c11\u51cb\u4ea1\uff0c\u8d77\u5230\u4fee\u590d\u80be\u5c0f\u7ba1\u7684\u4f5c\u7528\u3002\u8be5\u7814\u7a76\u4e3aMSC-exos\u5728\u80be\u5c0f\u7ba1\u4fee\u590d\u4e2d\u7684\u4f5c\u7528\u63d0\u4f9b\u4e86\u65b0\u89c6\u89d2\uff0c\u5e76\u5f3a\u8c03\u4e86MSC-exos\u4f5c\u4e3aAKI\u6cbb\u7597\u7b56\u7565\u7684\u6f5c\u529b\u3002<\/span><\/span><\/p>\n<p>\u00a0<\/p>\n<p><span><span><em>*\u4e1c\u5357\u5927\u5b66\u80be\u810f\u75c5\u7814\u7a76\u6240\u5218\u5fc5\u6210\u548c\u5415\u6797\u8389\u6559\u6388\u4e3a\u6587\u7ae0\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff0c\u8bfe\u9898\u7ec4\u535a\u58eb\u751f\u66f9\u5a67\u5a9b\u3001\u738b\u5f6c\u3001\u6c64\u6d9b\u6d9b\u4e3a\u6587\u7ae0\u7684\u5e76\u5217\u7b2c\u4e00\u4f5c\u8005\u3002<\/em><\/span><\/span><\/p>\n<p>\u00a0<\/p>\n<p><span><span><span><strong>\u4e1c\u5357\u5927\u5b66\u9644\u5c5e\u4e2d\u5927\u533b\u9662\u7b80\u4ecb<\/strong><\/span><\/span><\/span><\/p>\n<p><span><span>\u4e1c\u5357\u5927\u5b66\u9644\u5c5e\u4e2d\u5927\u533b\u9662\u59cb\u5efa\u4e8e1935\u5e74\uff0c\u5176\u524d\u8eab\u4e3a\u4e2d\u592e\u5927\u5b66\u533b\u5b66\u9662\u9644\u8bbe\u533b\u9662\uff0c\u5386\u7ecf\u7b2c\u4e94\u519b\u533b\u5927\u5b66\u9644\u5c5e\u533b\u9662\uff0c\u89e3\u653e\u519b84\u533b\u9662\u53ca\u5357\u4eac\u94c1\u9053\u533b\u5b66\u9662\u9644\u5c5e\u533b\u9662\u7b49\u51e0\u4e2a\u91cd\u8981\u5386\u53f2\u9636\u6bb5\u3002\u7ecf\u8fc783\u5e74\u7684\u53d1\u5c55\uff0c\u73b0\u5df2\u6210\u4e3a\u96c6\u533b\u7597\u3001\u6559\u5b66\u3001\u79d1\u7814\u4e3a\u4e00\u4f53\u7684\u5927\u578b\u7efc\u5408\u6027\u6559\u5b66\u533b\u9662\uff0c\u662f\u6c5f\u82cf\u7701\u552f\u4e00\u6559\u80b2\u90e8\u76f4\u5c5e\u201c\u53cc\u4e00\u6d41\u201d\u3001\u201c985\u201d\u3001\u201c211\u201d\u5de5\u7a0b\u91cd\u70b9\u5efa\u8bbe\u7684\u5927\u5b66\u9644\u5c5e\u533b\u9662\uff0c\u4e5f\u662f\u6c5f\u82cf\u7701\u9996\u6279\u901a\u8fc7\u536b\u751f\u90e8\u8bc4\u5ba1\u7684\u7efc\u5408\u6027\u4e09\u7ea7\u7532\u7b49\u533b\u9662\u3002<\/span><\/span><\/p>\n<p>\u00a0<\/p>\n<p><span><span><span>\u53c2\u8003\u6587\u732e\uff1a<\/span><\/span><\/span><\/p>\n<p><span><span><span>Cao JY, Wang B, Tang TT, Wen Y, LiZL, Feng ST, Wu M, Liu D, Yin D, Ma KL, Tang RN, Wu QL, Lan HY, Lv LL, Liu BC.Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury. Theranostics. 2021;11(11):5248-5266.<\/span><\/span><\/span><\/p>\n<p><span><span><span>https:\/\/www.thno.org\/v11p5248.htm<\/span><\/span><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><!--\/article detail-->\n<\/div>\n<\/div>\n<div>\n<div>\n<!--w-slide--><\/p>\n<div>\n<div>\n<div>\n<div>\n<div>\n<div><\/div>\n<\/div>\n<div>\n<div><\/div>\n<div>\n<div>\n                                            <\/div>\n<div><\/div>\n<div><\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n<p>        <!-- Bullet Navigator --><\/p>\n<div>\n<div>\n            <!-- bullet navigator item prototype --><\/p>\n<div><\/div>\n<\/div>\n<\/div>\n<p>        <!-- 1Arrow Navigator --><\/p>\n<div><span><br \/>\n            <i><\/i><br \/>\n        <\/span><\/div>\n<div><span><br \/>\n            <i><\/i><br \/>\n        <\/span><\/div>\n<\/p><\/div>\n<\/div>\n<p><!--\/w-slide--><\/p>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u81ea2019\u5e744\u670826\u65e5\uff0c\u8335\u51a0\u751f\u7269\u4e0e\u4e1c\u5357\u5927\u5b66\u9644\u5c5e\u4e2d\u5927\u533b\u9662\u6b63\u5f0f\u7b7e\u7f72\u300a\u751f\u7269\u533b\u5b66\u65b0\u6280\u672f\u7814\u7a76\u4e0e\u8f6c\u5316\u5e94\u7528\u6218\u7565\u5408\u4f5c\u534f\u8bae\u300b\u4ee5\u6765&hellip;&nbsp;<a href=\"https:\/\/wingor.abvnet.com\/en\/news\/%e5%96%9c%e8%ae%af%ef%bc%81%e8%8c%b5%e5%86%a0%e6%88%98%e7%95%a5%e5%90%88%e4%bd%9c%e5%8c%bb%e9%99%a2%e4%b8%9c%e5%a4%a7%e9%99%84%e5%b1%9e%e4%b8%ad%e5%a4%a7%e5%8c%bb%e9%99%a2%e5%8f%96%e5%be%97%e9%87%8d\/\" rel=\"bookmark\">Read More &raquo;<span class=\"screen-reader-text\">\u559c\u8baf\uff01\u8335\u51a0\u6218\u7565\u5408\u4f5c\u533b\u9662\u4e1c\u5927\u9644\u5c5e\u4e2d\u5927\u533b\u9662\u53d6\u5f97\u91cd\u5927\u8fdb\u5c55<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":1852,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[37],"tags":[],"class_list":["post-1851","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gsdt"],"desktop_mode_lock":null,"desktop_mode_contributors":[],"_links":{"self":[{"href":"https:\/\/wingor.abvnet.com\/en\/wp-json\/wp\/v2\/posts\/1851","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wingor.abvnet.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wingor.abvnet.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wingor.abvnet.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wingor.abvnet.com\/en\/wp-json\/wp\/v2\/comments?post=1851"}],"version-history":[{"count":0,"href":"https:\/\/wingor.abvnet.com\/en\/wp-json\/wp\/v2\/posts\/1851\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wingor.abvnet.com\/en\/wp-json\/wp\/v2\/media\/1852"}],"wp:attachment":[{"href":"https:\/\/wingor.abvnet.com\/en\/wp-json\/wp\/v2\/media?parent=1851"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wingor.abvnet.com\/en\/wp-json\/wp\/v2\/categories?post=1851"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wingor.abvnet.com\/en\/wp-json\/wp\/v2\/tags?post=1851"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}